Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere
DL Greiner, AA Rossini, JP Mordes - Clinical Immunology, 2001 - Elsevier
Type 1 diabetes in humans is a serious autoimmune disorder of children that is still poorly
understood, unpreventable, and irreversible. Study of its animal models, notably the NOD
mouse and BB rat, has generated a wealth of information concerning genetics and
immunopathogenesis, but that information has still not altered the way in which we treat
children with diabetes. In this review we attempt to identify the most promising avenues of
continuing research in these models and the most important issues that must be faced by the …
understood, unpreventable, and irreversible. Study of its animal models, notably the NOD
mouse and BB rat, has generated a wealth of information concerning genetics and
immunopathogenesis, but that information has still not altered the way in which we treat
children with diabetes. In this review we attempt to identify the most promising avenues of
continuing research in these models and the most important issues that must be faced by the …
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